| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| LEVOFLOXACIN (Paeds) (Levaquin) Mechanism of action: Fluoroquinolone antibiotic; inhibits bacterial DNA synthesis. Ref: 6, 44, 255, 256, 626 Last update: 2022-07-04 |
tablet: 250 mg, 500 mg, 750 mg oral suspension (BCCH): 50 mg/mL IV solution: 5 mg/mL in 5% dextrose injection |
Children: 6 mo to <5 yrs: 10 mg/kg/dose PO Q12H >=5 yrs: 10 mg/kg/dose PO once daily Maximum: 750 mg/day Adults: 500-750 mg PO once daily IV: same dosage as PO |
Oral bio-availability = 99%. Avoid concomitant administration with antacids, sucralfate, ferrous sulfate, calcium supplements; space doses by 2-4 hours. Dosage adjustment required in renal impairment. Risk of cartilage damage found in animal models, but not shown in humans. Use treatment dosing for prophylaxis of bloodstream infections in select oncology patients. Refer to Prophylaxis of Bloodstream Infections guideline for more information Standard Prescription: levofloxacin __ mg PO Q__H (__ mg/kg/dose) levofloxacin __ mg IV Q__H (__ mg/kg/dose) |