DRUG SUPPLIED DOSE COMMENTS
ICATIBANT (Paeds)
(Firazyr)

Mechanism of action:

Icatibant acts as a bradykinin inhibitor by blocking the binding of native bradykinin to the bradykinin B2 receptor


Ref: 142, 293


Last update: 2019-04-03
Single Dose Pre-filled Syringe (PFS): 30 mg/3 mL

Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) type I/II acute, episodic attack

Children (>=2 years) and adolescents:
0.4 mg/kg/dose SC x 1 dose
Maximum: 30 mg/dose

Note: in adults doses may be repeated after 6 hrs, up to a maximum of 3 doses total in 24hr

For slow subcutaneous injection in the abdominal region

Injection site reactions  are common (eg. erythema, swelling, warm sensation, burning, itching and/or cutaneous pain)


Standard Prescription:

Icatibant __mg SC one dose (__mg/kg/dose)