| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| BACLOFEN (Paeds) (Lioresal) Mechanism of action: Skeletal muscle relaxant Ref: 44, 491, 492, 493, 494 Luc QN, Querubin J. Clinical Management of Dystonia in Childhood. Paediatr Drugs. 2017 Oct;19(5):447-461. Goyal V, Laisram N, Wadhwa RK, Kothari SY. Prospective randomized study of oral diazepam and baclofen on spasticity in cerebral palsy. J Clin Diagn Res. 2016;10(6) :RC01-RC5. Lubsch L, Habersang R, Haase M, Luedtke S. Oral baclofen and clonidine for treatment of spasticity in children. J Child Neurol. 2006;21(12):1090-1092. Scheinberg A, Hall K, Lam LT, O'Flaherty S. Oral baclofen in children with cerebral palsy: a double-blind cross-over pilot study. J Paediatr Child Health. 2006;42(11):715-20. Last update: 2021-11-08 |
Tablet: 10 mg, 20mg Suspension (BCCH): 10 mg/mL Intrathecal injection: 2000 mcg/mL |
Dystonia Initial: 0.1 mg/kg/dose PO TID Titrate by 0.1-0.3 mg/kg/day every 3-7 days to effect Target dose of 1-2 mg/kg/day Spasticity Children <2 yrs : Initial: 2.5 mg PO once to TID Titrate by 5 mg increments every 3-7 days to a maximum of 40 mg/24 hr 2-7 yrs: Initial: 2.5 mg PO once to TIDTitrate by 5 mg increments every 3-7 days to a maximum of 60 mg/24 hr >8 years: Initial: 5 mg PO once to TIDTitrate by 5 mg increments every 3-7 days to a maximum of 200 mg/24 hrs Intrathecal Usual maintenance: 100-2000 mcg/day (requires careful titration) |
May cause drowsiness, sedation, confusion, nausea, vomiting, constipation. A slower dose titration can minimize side effects. May exacerbate seizures. Worsens preexisting axial hypotonia at high doses. Avoid abrupt withdrawal (hallucinations, seizures, worsening spasticity, confusion). Should be discontinued over at least 1-2 weeks or longer. Maximum effect for muscle relaxation is not seen for 5-7 days. Standard Prescription: baclofen __mg PO Q_H (__mg/24hr) |