DRUG	SUPPLIED	DOSE	COMMENTS
METHIMAZOLE (Paeds) (Tapazole) Mechanism of action: Anti-thyroid medication Ref: 44, 287 Last update: 2022-04-08	tablet: 5 mg, 10 mg	Hyperthyroidism/Graves Disease Children: Initial: 0.25 - 0.5 mg/kg/dose daily-TID (0.25 - 1 mg/kg/day) PO (Max 60 mg/day). Adults: Initial: 15 - 60 mg/day PO Maintenance: progressively decrease to 50% or less of initial dose	Propylthiouracil, another anti-thyroid medication, is no longer recommended as first-line therapy because of hepatic and renal toxicity Start decreasing the dose when patient is euthyroid and TSH become detectable (usually after 1-2 months). Adjust dose to achieve TSH serum concentrations in the normal range Can be given 1-3 times a day. Adherence is better with once-daily dosage. Standard Prescription: Methimazole __ mg PO daily (__ mg/kg/day)