| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| MONTELUKAST (Paeds) (Singulair) Mechanism of action: Non-steriodal leukotriene receptor antagonist Ref: 44, 127, 275 Last update: 2022-07-06 |
oral granules: 4 mg (not stocked at BCCH) chewable tablets: 4 mg, 5 mg tablets: 10 mg |
Children < 6 years old: 4 mg PO QHS Children 6-14 years old: 5 mg PO QHS Adults and Children >= 15 years old: 10 mg PO QHS |
May be used as adjunctive therapy with moderate to high doses of inhaled corticosteroids. May have steroid-sparing properties; allowing for better asthma control at a reduced dose of inhaled corticosteroids. Metabolized extensively by CYP 3A4, 2C8, 2C9 Side effects: headache, flu-like symptoms, abdominal pain, cough. Neuropsychiatric events (abnormal dreams, hallucinations, suicide ideation/behavior, tremors) and development of Churg-Strauss syndrome have been reported in a few case reports. Standard Prescription: Montelucast __mg PO daily HS |