DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
CEFTRIAXONE (Paeds) (Rocephin) Mechanism of action: Third-generation cephalosporin antibiotic Ref: 6, 44, 229 Last update: 2022-06-16 |
Injection: 0.25 g, 1 g, 2 g vials | Children: Mild to Moderate Infections: 50-75 mg/kg/dose IM/IV once dailySerious Infections: 50 mg/kg/dose IM/IV Q12H. (100 mg/kg/24 h given once daily or div Q12H) Maximum: 4000 mg/24 hr (meningitis) or 2000 mg/24 hr (other infections) Adults: Usual dose: 1-2 g IM/IV Q12-24H Max 4 g/24 hr |
Spectrum of activity of ceftriaxone is very similar to cefotaxime. For IM USE ONLY, ceftriaxone may be reconstituted with 1% lidocaine. Due to the risk of ceftriaxone-calcium precipitates, which have caused serious cardiopulmonary events in infants, ceftriaxone must not be mixed or administered simultaneously with calcium containing IV solutions, including parenteral nutrition, neither co-administered nor via Y-site. Infants > 28 days & children: ceftriaxone and calcium-containing solutions may be administered sequentially to one another if the infusion lines are thoroughly flushed between infusions with a compatible fluid. Neonates: Ceftriaxone is contraindicated if they require (or are expected to require) treatment with calcium-containing IV solutions, including TPN. Ceftriaxone displaces bilirubin from albumin binding sites which can result in hyperbilirubinemia; use caution in neonates. Standard Prescription: ceftriaxone__mg IV Q H ( mg/kg/24 hr) |