DRUG	SUPPLIED	DOSE	COMMENTS
CAPTOPRIL (Paeds) (Capoten) Mechanism of action: Angiotensin-Converting Enzyme (ACE) inhibitor Ref: 1, 29, 141, 192, 193 Last update: 2018-12-09	Tablet:  6.25 mg, 12.5 mg, 25 mg, 50 mg Suspension (BCCH): 1 mg/mL	Neonates: refer to pink pages as doses are different in this age group Infants and Children: Initial: 0.1-0.5 mg/kg/dose PO BID-TID. *Titrate dose Q8-24H to a max of 6 mg/kg/24 hr Adolescents: Initial: 6.25-12.5 mg/dose PO BIDTID. (Max 6 mg/kg/24 hr or 450 mg/24 hr) Adults: 12.5-25mg PO TID Increase weekly if necessary by 25 mg/dose to a max.dose of 450 mg/24 hr	Reduce dose with impaired renal function. Ensure adequate hydration; monitor serum creatinine and potassium after starting or increasing dose. Severe hypotension may occur in patients who are sodium and/or volume depleted; use lower initial doses in these patients caution in bilateral renal artery stenosis contraindicated in all stages of pregnancy; discuss contraception with all females of childbearing age. Onset of hypotensive effect: 15 min.; peak 60-90 min.,duration 6-8 hrs Dose titration: dose may be increased with each dosing interval; monitor vitals every 30 minutes x 2 after each dose change 37.5 mg of captopril is approximately equivalent to 5 mg of enalapril or 2.5 mg of ramipril May cause hyperkalemia; caution with potassium supplements and sparing agents NSAIDs may blunt the hypotensive effects Standard Prescription: captopril __mg PO__(frequency) (__mg/kg/dose)