| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| CEFUROXIME (Paeds) (Ceftin = cefuroxime axetil [po], Zinacef) Mechanism of action: Second generation cephalosporin antibiotic Ref: 6, 44, 227, 614 Last update: 2022-06-16 |
injection: 750 mg, 1.5 g tablets: 250 mg, 500 mg |
Children: 25-50 mg/kg/dose IV Q8H. Max. 2000 mg/dose 50 mg/kg/dose IV Q8H. Max 1500 mg/dose 750-1500 mg/dose IV Q8H Children: 10-15 mg/kg/dose PO BID. Max. 500 mg/dose Osteomyelitis: 33 mg/kg/dose PO TID. Max. 1000 mg/dose 250-500 mg/dose PO BID |
Bioavailability of the oral tablet is increased when administered with food. Cefuroxime axetil oral suspension is not palatable and is less bioavailable than the tablet; see cefprozil for second generation oral cephalosporin. Dosage adjustment required in renal impairment. Standard Prescription: cefuroxime __mg IV/IM Q H (__mg/kg/24h) cefuroxime __mg PO BID (__mg/kg/24h) |