DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
COTRIMOXAZOLE (Paeds) (Septra, TMP-SMX, Novo-Trimel, Apo-Sulfatrim) Mechanism of action: Sulfonamide antibiotic; combination of trimethoprim and sulfamethoxazole in 1:5 ratio Ref: 6, 44, 224, 225 Last update: 2022-06-16 |
tablet: trimethoprim 80 mg/ sulfamethoxazole 400 mg (DS tablets: TMP 160 mg/SMX 800 mg are available but not stocked at BCCH) oral suspension: trimethoprim 8 mg/ sulfamethoxazole 40 mg per mL injection: trimethoprim 16 mg/ sulfamethoxazole 80 mg per mL |
Mild to Moderate Infections: 4-6 mg TMP/20-30 mg SMX/kg/dose PO/IV Q12H (for PO dosing: 0.5-0.75 mL/kg/dose PO Q12H). Severe Infections (pneumocystis jiroveci): 5 mg TMP/25 mg SMX/kg/dose PO/IV Q6H x 21 days.Cystic Fibrosis: 6 mg TMP/30 mg SMX/kg/dose PO Q12H. May increase to 5 mg TMP/25 mg SMX/kg/dose PO/IV Q6H for severe infections. PO Max 320 mg TMP/doseProphylaxis of Pneumocystis jiroveci in Immunocompromised Patients (non-HIV): 2.5 mg TMP/12.5 mg SMX/kg/dose PO Q12H on 2 consecutive days per week (approximately 0.3 mL/kg/dose). Prophylaxis for U.T.I.: 2 mg- TMP/10 mg SMX/kg/dose PO once daily (i.e. 0.25-mL/kg/dose).Adult Max: Mild to Moderate Infections:160 mg TMP/800 mg SMX/dose PO Q12H 320 mg TMP/1600 mg SMX/dose PO Q6-8H |
Bioavailability 90-100%. Use IV form only when PO form cannot be administered. 10 mL oral liquid = 1 tablet. TMP = trimethoprim. SMX = sulfamethoxazole. Not recommended for children <1 month old Monitor for neutropenia and elevated liver enzymes with higher doses and longer treatment duration. Standard Prescription: Cotrimoxazole __mg TMP/__mg SMX IV{PO} Q__H (__TMP/__SMX/kg/24hr) |