DRUG SUPPLIED DOSE COMMENTS
CHLORAMPHENICOL (Paeds)


Mechanism of action:

Bacteriostatic antibiotic, inhibiting protein synthesis, preventing protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome.



Ref: 6, 44



Last update: 2022-06-16
Injection: 1 g

 Meningitis:  
18.75-25 mg/kg/dose IV Q6H
Max: 1 g/dose
Other infections:
12.5-25 mg/kg/dose IV  Q6H
Max: 1000 mg/dose
 Serious blood dyscrasias have occurred with short and long-term use. Monitoring CBC during therapy is recommended.

Therapeutic Peak Levels: 15-25 mg/L. Levels > 50 mg/L are associated with a greater incidence of toxic effects.

Refer to Therapeutic Drug Monitoring Table (white pages in print copy).

Measurement of serum levels is subject to approval of a clinical microbiologist.

Use with caution in G6PD deficiency, renal or hepatic dysfunction and in neonates.

Standard Prescription:

chloramphenicol __mg IV Q    H (__mg/kg/24h)

chloramphenicol 0.5% eye drops- Instill one drop in__eye Q__H

chloramphenicol 1% eye ointment- Apply to __eye Q__H