| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| CHLORPROMAZINE (Paeds) (Largactil) Mechanism of action: Low-potency conventional antipsychotic (better used as a sedative than antipsychotic). Chlorpromazine is a very effective antagonist of D2 dopamine receptors. Ref: 44, 83 Last update: 2021-06-22 |
tablet: 25 mg, 50 mg, 100 mg Note : injectable formulation discontinued from Canadian market. |
Children > 5 years: 0.5-1 mg/kg/dose PO Q6H (2-4 mg/kg/24 hr PO divided Q4-6H) Maximum Dose: 5-12 years old: 75 mg/24 hr. Adolescents may require 150 mg/ 24 hr. (Initial 24 hr maximum limits shown above may be adjusted to higher 24 hr maximum limits with repeated use over time if necessary) |
Low-potency conventional antipsychotic (better used as a sedative than antipsychotic) Causes sedation, hypotension and sialorrhea. May cause hypotension, tachycardia, dizziness, QTc interval prolongation, lowered seizure threshold, anticholinergic symptoms. Low risk of extrapyramidal symptoms (EPS); reversible with diphenhydramine or benztropine if EPS occurs. EPS may be more prominent in neurodiverse patients. May cause drug interactions via CYP 2D6 inhibition. Standard Prescription: chlorpromazine __mg PO Q__H (__mg/kg/24hr) |