DRUG SUPPLIED DOSE COMMENTS
CIPROFLOXACIN (Paeds)
(Cipro)

Mechanism of action:

Fluoroquinolone antibiotic


Ref: 6, 44, 46, 76, 474


Last update: 2022-06-16		 tablet: 250 mg, 500 mg
oral suspension: 100 mg/mL
injection: 2 mg/mL
eye drops: 0.3%

 Oral: 10-20 mg/kg/dose PO BID.  Max: 750 mg/dose
IV: 10-15 mg/kg/dose IV  Q12H. Max 400 mg/dose

For Pseudomonas aeruginosa treatment: 10 mg/kg/dose IV Q8H. Max: 400 mg/dose

Cystic Fibrosis Patients:
Oral: 20 mg/kg/dose PO Q12H. Max: 1000 mg/dose
IV: 10 mg/kg/dose IV Q8H. Max:  400 mg/dose

Eye drops:
Bacterial conjunctivitis:
1-2 drops q2h while awake x 2 days, then 1-2 drops q4h while awake x 5 days

Corneal ulcers:
Day 1: 2 drops Q15 min. x 6 hr, then 2 drops Q30 mins
Day 2: 2 drops Q1H
Days 3-14: 2 drops Q4H

 Bioavailability 70-80%.

Ciprofloxacin suspension should not be administered through G-tubes as blockage can result.

Not routinely first-line therapy, but can be considered a reasonable alternative in some situations.

Monitor for arthralgias, tendonitis and maintain fluid intake to prevent crystalluria.

Ciprofloxacin can increase effects and/or toxicity of theophylline, warfarin, cyclosporine and caffeine

Avoid concomitant administration with divalent or trivalent cations (e.g. antacids, iron Fe 3+, calcium supplements Ca 2+ ), sucralfate; space doses by 2-6 hours.


Standard Prescription:

ciprofloxacin__mg PO Q__H (__mg/kg/day)
ciprofloxacin__mg IV Q__H (__mg/kg/day)