| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| CLOBAZAM (Paeds) (Frisium) Mechanism of action: Benzodiazepine; anticonvulsant, A GABAa receptor agonist and may affect sodium channels and voltage-sensitive calcium channels. Ref: 32, 44 , 362 Last update: 2022-06-17 |
tablet: 10 mg oral liquid (BCCH): 1 mg/mL |
Seizures: Children > 2 years <=30 kg: Initial: 2.5-5 mg/dose PO daily Increment: 2.5-5 mg/dose PO daily every 5-7 days Maintenance: 0.5-1 mg/kg/dose PO daily (Divide doses > 20 mg to BID) Maximum: 30 mg/dose PO daily (In rare cases, may use higher maximum based on individual clinical response) > 30 kg: Initial: 5-10 mg/dose PO daily Increment: 5-10 mg/dose PO daily every 5-7 days Maintenance: 0.5-1 mg/kg/dose PO daily. (Consider dividing doses > 20 mg to BID) Maximum: 30 mg/dose PO daily (In rare cases, may use higher maximum based on individual clinical response) |
Use lowest effective dose Patients who show no response to 1 mg/kg/24 hr are unlikely to respond to higher doses If daily dose is divided, the higher portion should be taken at night. CYP2C19 poor metabolizers may require slower titration Adverse effects: drooling, sedation, increased appetite, paradoxical reactions, behavioural changes (more likely in patients with ADHD or previous behavioural problem Standard Prescription: clobazam__mg PO Q__H (__mg/kg/24hr) |