| DRUG | SUPPLIED | DOSE | COMMENTS |
|---|---|---|---|
| CLONIDINE (Paeds) (Catapres, Dixarit) Mechanism of action: Alpha-adrenergic agonist stimulating central (brain stem) alpha receptors. Ref: 32, 44, 83 Last update: 2022-06-16 |
tablet: 0.025 mg, 0.1 mg, 0.2 mg suspension (BCCH): 0.01 mg/mL |
ADHD/Disruptive Behaviour: Initial dose: 1 micrograms/kg/dose TID to QID Target dose: up to 2.5 micrograms/kg/dose TID to QID Usual maximum dose: 10 micrograms/kg/24 hr; pts > 45 kg: 400 micrograms/24 hr Adjunct to analgesia: 1-4 micrograms/kg/dose PO Q4-6H Titrate upwards if needed and as tolerated to a maximum of 10 micrograms/kg/24 hr. |
Gradually titrate up to target dosage over 1-2 weeks to prevent somnolence, dizziness, hypotension and syncope. To discontinue after prolonged use (>7 days on clonidine and/or dexmedetomidine), gradually decrease dose o(reduce dose by 25% every 3-7 days) to avoid withdrawal syndrome which may include rebound hypertension. Withhold or reduce dose if excessive hypotension or bradycardia. Dose modification may be required in renal impairment. High potential for 10-fold dosing errors. Make dosage calculations/conversions carefully (ensure proper units used): 25 micrograms equals 0.025 mg 100 micrograms equals 0.1 mg Standard Prescription: clonidine__mcg PO Q__H (__mcg/kg/24hr) |