AMINOPHYLLINE
(theophylline ethylene diamine)Standard Prescription
aminophylline__mg/kg/hr IV infusion
Dosages
See also theophylline monograph.
Bronchodilator:
IV loading dose: 6 mg/kg IV over 20 min. Reduce dose by 50% if patient has had theophylline in previous 24 hr.
IV Infusions:
6 wk to 6 mo: 0.5 mg/kg/hr
6 to 12 mo: 0.6 to 0.7 mg/kg/hr
1 to 9 yr: 1 to 1.2 mg/kg/hr
9 to 12 yr & adult smokers: 0.9 mg/kg/hr.
12 to 16 yr & non-smoking adults: 0.7 mg/kg/hr.
Dosage must be adjusted using levels:
Monitor levels to determine dosing: 30 min following loading dose & 6 hrs after start of infusion then q24 hrs
Bronchodilator:
IV loading dose: 6 mg/kg IV over 20 min. Reduce dose by 50% if patient has had theophylline in previous 24 hr.
IV Infusions:
6 wk to 6 mo: 0.5 mg/kg/hr
6 to 12 mo: 0.6 to 0.7 mg/kg/hr
1 to 9 yr: 1 to 1.2 mg/kg/hr
9 to 12 yr & adult smokers: 0.9 mg/kg/hr.
12 to 16 yr & non-smoking adults: 0.7 mg/kg/hr.
Dosage must be adjusted using levels:
Monitor levels to determine dosing: 30 min following loading dose & 6 hrs after start of infusion then q24 hrs
Mechanism of Action
Bronchodilator; nonselective adenosine receptor antagonist and phosphodiesterase inhibitor.
Forms Supplied
Injection: 25 mg/mL
Comments
Aminophylline contains 80% theophylline; to convert to oral theophylline: multiply aminophylline dose in mg/24 hr by 0.8 = theophylline daily dose
Use ideal body weight for all dose calculations.
Target serum theophylline level is 55-110 μmol/L for bronchodilation.
For loading doses, each 1.25 mg/kg of aminophylline raises the serum theophylline level approximately 11 umol/L
Side Effects: restlessness, GI upset, dysrhythmias, seizures, shock
Theophylline levels increase with allopurinol, fluvoxamine, isoniazide, macrolide antibiotics (e.g. erythromycin), quinolones antibiotics (e.g. ciprofloxacin)
Theophylline levels decrease with carbamazepine, phenobarbital, phenytoin, isoproterenol.
See C&W Guidelines for Theophylline.
Use ideal body weight for all dose calculations.
Target serum theophylline level is 55-110 μmol/L for bronchodilation.
For loading doses, each 1.25 mg/kg of aminophylline raises the serum theophylline level approximately 11 umol/L
Side Effects: restlessness, GI upset, dysrhythmias, seizures, shock
Theophylline levels increase with allopurinol, fluvoxamine, isoniazide, macrolide antibiotics (e.g. erythromycin), quinolones antibiotics (e.g. ciprofloxacin)
Theophylline levels decrease with carbamazepine, phenobarbital, phenytoin, isoproterenol.
See C&W Guidelines for Theophylline.
References
1, 44
Last Edited
2018-05-13 04:35:47