DIPYRIDAMOLE
(Persantine)Standard Prescription
dipyridamole__mg PO Q__H (__mg/kg/24hr)
Dosages
Children:
2-5 mg/kg/24 hr PO div. TID.
Post-op Ventricular Assist Device (Berlin Heart):
1 mg/kg/dose PO Q6H
2-5 mg/kg/24 hr PO div. TID.
Post-op Ventricular Assist Device (Berlin Heart):
1 mg/kg/dose PO Q6H
Mechanism of Action
Antiplatelet; vasodilator.
Dipyridamole:
1) inhibits the phosphodiesterase enzymes that normally break down cAMP (increasing cellular cAMP levels and blocking the platelet aggregation response to ADP) and/or cGMP.
2) inhibits the cellular reuptake of adenosine into platelets, red blood cells, and endothelial cells, leading to increased extracellular concentrations of adenosine.
Forms Supplied
tablet: 25 mg, 50 mg, 75 mg
Comments
ASA alternative.
Variable oral absorption; to optimize take on an empty stomach (1 hour before or 2 hours after meals)
Has peripheral vasodilator effects: use with caution in patients with hypotension
In patients with Berlin Hearts dipyridamole is used in combination with ASA as part of Berlin Heart anticoagulation protocol - see Berlin Heart on Team site at BCCH
Variable oral absorption; to optimize take on an empty stomach (1 hour before or 2 hours after meals)
Has peripheral vasodilator effects: use with caution in patients with hypotension
In patients with Berlin Hearts dipyridamole is used in combination with ASA as part of Berlin Heart anticoagulation protocol - see Berlin Heart on Team site at BCCH
References
90, 149
Last Edited
2019-01-22 17:51:22