DOXYCYCLINE
Standard Prescription
doxycycline__mg IV{PO} Q__H (__mg/kg/24hr)
Dosages
Children <45 kg:
2.2 mg/kg/dose PO/IV Q12H Maximum: 200 mg/day
Children >45 kg and adults:
100 mg/dose PO/IV Q12H
Anthrax: (if strain proven susceptible) 2.2 mg/kg/dose IV Q12H x 60 days (convert to PO when clinically appropriate)
Maximum: 200 mg/day
2.2 mg/kg/dose PO/IV Q12H Maximum: 200 mg/day
Children >45 kg and adults:
100 mg/dose PO/IV Q12H
Anthrax: (if strain proven susceptible) 2.2 mg/kg/dose IV Q12H x 60 days (convert to PO when clinically appropriate)
Maximum: 200 mg/day
*Note: Initial treatment for anthrax should include two or more agents as per CDC recommendations.
Lyme Disease Prophylaxis:
4.4 mg/kg/dose PO once within 72 hours of tick bite
Maximum: 200 mg/dose
4.4 mg/kg/dose PO once within 72 hours of tick bite
Maximum: 200 mg/dose
Mechanism of Action
Tetracycline antibiotic
Forms Supplied
capsules: 100 mg
injection: 100 mg/vial (available through the Special Access Program only)
injection: 100 mg/vial (available through the Special Access Program only)
Comments
Refer to BCCH Lyme Disease Treatment Algorithm for further guidance.
Use of doxycycline in children <8 years of age should be reserved for severe infections or when other alternatives are unavailable due to risk for tooth enamel hypoplasia and permanent discolouration of the developing teeth (eg. Anthrax, rickettsial disease, or ehrlichiosis).
Doxycycline may be less likely to cause teeth staining than tetracycline. Teeth staining is dose related, so duration of therapy should be minimized
Avoid iron, calcium and dairy products for at least one hour before or two hours after doxycycline administration.
Photosensitivity may occur (avoid prolonged exposure to sunlight).
References
6, 44
Last Edited
2022-06-18 21:10:10