ENALAPRIL
(Vasotec)Standard Prescription
enalapril__mg PO__(frequency) (__mg/kg/24hr)
Dosages
Infants and Children:
0.05-0.1 mg/kg/dose PO Q12-24H
Titrate dose every 3-5 days. Maximum: 0.6 mg/kg/24 hr. or 40 mg/24 hr.
Adolescent/adults:
Initial: 2.5-5 mg/24 hr PO then increase as required to a maximum of 40 mg/24 hr.
0.05-0.1 mg/kg/dose PO Q12-24H
Titrate dose every 3-5 days. Maximum: 0.6 mg/kg/24 hr. or 40 mg/24 hr.
Adolescent/adults:
Initial: 2.5-5 mg/24 hr PO then increase as required to a maximum of 40 mg/24 hr.
Mechanism of Action
Angiotensin-converting enzyme (ACE) inhibitor
Forms Supplied
tablet: 5 mg, 10 mg
suspension (BCCH): 1 mg/mL
(also available but not stocked at BCCH: 2.5 mg, 20 mg tablets)
suspension (BCCH): 1 mg/mL
(also available but not stocked at BCCH: 2.5 mg, 20 mg tablets)
Comments
Onset of action: within 1 hr.; peak effect 4-8 hr.
Comparable to captopril but has the advantage of once daily dosing in most patients and can be given without regard to meals.
contraindicated in ALL stages of pregnancy; discuss contraception requirement with all females of child-bearing age.
caution in bilateral renal artery stenosis.
Ensure adequate hydration and monitor serum creatinine and potassium after starting or increasing dose.
Severe hypotension may occur in patients who are sodium and/or volume depleted; use lower initial doses in these patients.
ACE inhibitor equivalencies:
captopril 37.5 mg = enalapril 5 mg = ramipril 2.5 mg
patients titrated on captopril may be converted to an equivalent dose of enalapril without re-titration.
Comparable to captopril but has the advantage of once daily dosing in most patients and can be given without regard to meals.
contraindicated in ALL stages of pregnancy; discuss contraception requirement with all females of child-bearing age.
caution in bilateral renal artery stenosis.
Ensure adequate hydration and monitor serum creatinine and potassium after starting or increasing dose.
Severe hypotension may occur in patients who are sodium and/or volume depleted; use lower initial doses in these patients.
ACE inhibitor equivalencies:
captopril 37.5 mg = enalapril 5 mg = ramipril 2.5 mg
patients titrated on captopril may be converted to an equivalent dose of enalapril without re-titration.
References
44, 60 141
Last Edited
2019-01-23 01:08:56