ETHAMBUTOL

 (Etibi)

Standard Prescription

ethambutol__mg PO__(frequency) (__mg/kg/dose)

Dosages

Tuberculosis and Non-TB mycobacterial infections:  

15 -25 mg/kg/dose PO daily or 50 mg/kg/dose twice weekly. 
Maximum:  2.5 g/dose.

Mechanism of Action

Antimycobacterial agent. It is bacteriostatic against actively growing bacilli. It inhibits the enzyme arabinosyl transferase leading to increased permeability of the cell wall.

Forms Supplied

tablet: 100 mg, 400 mg

Comments

Adverse effects: optic neuritis (usually reversible), decreased red/green colour discrimination, GI upset and hypersensitivity.

Avoid use in children in whom visual acuity and color perception cannot be assessed.

Commonly given concurrently with rifampin or other TB drugs.

References

6, 44, 134, 167, 203

Last Edited

2022-06-24 04:24:49