FLECAINIDE
(Tambocor)Standard Prescription
flecainide__mg PO__(frequency) (__mg/kg/24hr) or (__mg/m2/24hr)
Dosages
Infants/children:
Initial: 16-35 mg/m2/dose PO Q8H
Usual: 35-50 mg/m2/dose PO Q8H
Maximum: 200 mg/m2/24 hr
OR
Initial: 0.3-1 mg/kg/dose PO Q8H
Usual: 1-2 mg/kg/dose PO Q8H
Maximum: 8 mg/kg/24 hr
(consider BID dosing in older children)
Initial: 16-35 mg/m2/dose PO Q8H
Usual: 35-50 mg/m2/dose PO Q8H
Maximum: 200 mg/m2/24 hr
OR
Initial: 0.3-1 mg/kg/dose PO Q8H
Usual: 1-2 mg/kg/dose PO Q8H
Maximum: 8 mg/kg/24 hr
(consider BID dosing in older children)
Mechanism of Action
Antiarrhythmic agent, Class IC
Forms Supplied
Tablet: 50 mg, 100 mg
Liquid (BCCH): 20 mg/mL
Liquid (BCCH): 20 mg/mL
Comments
Amiodarone increases flecainide levels; decrease flecainide dose by 30-50% if used in combination with amiodarone (CYP450 2D6 substrate).
Use with caution in presence of CHD; may aggravate LV failure, sinus bradycardia and pre-existing ventricular arrhythmias.
Monitor QRS duration, increased PR interval.
Dairy products (milk, infant formula) may decrease absorption of flecainide. Avoid concurrent administration with formula feeds.
Reduce dose in renal failure.
References
44, 141, 242, 590
Last Edited
2022-06-25 22:25:36