HYDROXYCHLOROQUINE SULFATE
(Plaquenil)Standard Prescription
hydroxychloroquine__mg PO weekly (__mg/kg/dose)
Acute Malaria:
hydroxychloroquine__mg PO x 1 dose (__mg/kg/dose) then
hydroxychloroquine__mg PO x 1 dose (__mg/kg/dose) 6 hours after first dose then
hydroxychloroquine__mg PO Q H x__doses (__mg/kg/dose)
Acute Malaria:
hydroxychloroquine__mg PO x 1 dose (__mg/kg/dose) then
hydroxychloroquine__mg PO x 1 dose (__mg/kg/dose) 6 hours after first dose then
hydroxychloroquine__mg PO Q H x__doses (__mg/kg/dose)
Dosages
[Doses in terms of mg hydroxychloroquine base for malaria].
Doses should be calculated based on lean body mass.
Children:
Acute Malaria Attack:
10 mg/kg/dose PO (Max 620 mg), followed by 5 mg/kg/dose PO at 6 hr after first dose (Max 310 mg), then 5 mg/kg/dose PO 18 hours after second dose, then 5 mg/kg/dose PO at 24hr after third dose.
Malaria Prophylaxis:
5 mg base/kg PO weekly (see Comments).
Maximum 310 mg/dose.
Doses should be calculated based on lean body mass.
Children:
Acute Malaria Attack:
10 mg/kg/dose PO (Max 620 mg), followed by 5 mg/kg/dose PO at 6 hr after first dose (Max 310 mg), then 5 mg/kg/dose PO 18 hours after second dose, then 5 mg/kg/dose PO at 24hr after third dose.
Malaria Prophylaxis:
5 mg base/kg PO weekly (see Comments).
Maximum 310 mg/dose.
[Doses in terms of mg hydroxychloroquine sulfate for JIA/SLE]
SLE and other rheumatic diseases:
Usual: 4-6.5 mg/kg/dose PO daily
Maximum: 7 mg/kg/dose PO daily (Maximum 400 mg/day)
Mechanism of Action
Antimalarial
Forms Supplied
tablet: 200 mg (= 155 mg hydroxychloroquine base)
Comments
Use only for patients who have documented P. vivax, P. ovale or P. malariae malaria or who have traveled to an area with chloroquinesusceptible P. falciparum malaria
Prophylactic dose should begin 1 week before exposure and continue for 4 weeks after leaving endemic area.
Chronic use requires color vision and visual field monitoring every 12 months.
Prophylactic dose should begin 1 week before exposure and continue for 4 weeks after leaving endemic area.
Chronic use requires color vision and visual field monitoring every 12 months.
References
6, 22, 45
Last Edited
2022-07-03 02:57:03