IRON SUCROSE COMPLEX
(Venofer)Standard Prescription
iron sucrose__ mg Fe (__mg/kg/day) IV___(frequency)
Dosages
Note: Sodium ferric gluconate (Ferrlecit) is the iron of choice in the chronic kidney disease population.
Treatment of iron deficiency:
1. Calculate total iron deficit:
Patients <= 35 kg:
Patients > 35 kg:
2. Maximum daily dose is 7 mg/kg/day (up to 300 mg). If the total iron deficit exceeds the maximum daily dose, the total dose must be divided and given Every 3-7 days until total dose administered.
Treatment of iron deficiency:
1. Calculate total iron deficit:
Patients <= 35 kg:
Total iron deficit (mg) =
[body weight (kg) x (130 g/L - Hb (g/L)) x 0.24] + 15 mg/kg
Where 130 g/L = target haemoglobin level, and 15 mg/kg = depot iron
Patients > 35 kg:
Total iron deficit (mg) =
[body weight (kg) x (150 g/L - Hb (g/L)) x 0.24] + 500 mg
Where 150 g/L = target haemoglobin level, and 500 mg = depot iron
2. Maximum daily dose is 7 mg/kg/day (up to 300 mg). If the total iron deficit exceeds the maximum daily dose, the total dose must be divided and given Every 3-7 days until total dose administered.
Mechanism of Action
Iron salt for parenteral iron therapy
Forms Supplied
injection: 100 mg elemental Fe/5 mL amp.
Comments
Iron sucrose complex is reported to cause less adverse effects and less allergic/anaphylactic reactions than iron dextran.
Test doses are not required.
Although there is literature citing use of maximum single dose of 500 mg, all serious adverse reactions to iron sucrose have occurred with doses over 300 mg.
See Parenteral Manual for monitoring guidelines
Test doses are not required.
Although there is literature citing use of maximum single dose of 500 mg, all serious adverse reactions to iron sucrose have occurred with doses over 300 mg.
See Parenteral Manual for monitoring guidelines
References
44, 113
Last Edited
2019-04-04 18:50:25