ISOPROTERENOL
(Isuprel)Standard Prescription
isoproterenol __ mcg/kg/min continuous IV infusion
Dosages
For use by continuous infusion in Critical Care areas. Central line administration preferred.
Chronotrope/Inotrope:
Adults: 2 - 20 mcg/min
Chronotrope/Inotrope:
Neonates & Children: 0.025-2 mcg/kg/min. or titrate to effect
Adults: 2 - 20 mcg/min
Protect from light.
Discard discolored or precipitated solutions.
Change solution at 96 hours.
Discard discolored or precipitated solutions.
Change solution at 96 hours.
Mechanism of Action
Primarily inotropic and chronotropic agent with beta 1 and beta 2 agonist activity. Non selective pulmonary and systemic vasodilator effects.
Forms Supplied
injection: 0.2 mg/mL - 1 mL amp., 5 mL vial
pH = 3.5 - 4.5, Osmolality = 277
Contains sodium chloride, sodium lactate, lactic acid, metabisulfite
25 mcg/mL
pH = 3.5 - 4.5, Osmolality = 277
Contains sodium chloride, sodium lactate, lactic acid, metabisulfite
Standard concentrations for Critical Care:
Add 3.13 mL of 1:5000 to 21.87 mL D5W to make 25 mL of 25 mcg/mL
50 mcg/mL
Add 6.25 mL of 1:5000 to 18.75 mL D5W to make 25 mL of 50 mcg/mL
100 mcg/mL
Add 12.5 mL of 1:5000 to 12.5 mL D5W to make 25 mL of 100 mcg/mL
50 mcg/mL
Add 6.25 mL of 1:5000 to 18.75 mL D5W to make 25 mL of 50 mcg/mL
100 mcg/mL
Add 12.5 mL of 1:5000 to 12.5 mL D5W to make 25 mL of 100 mcg/mL
Use Alaris Pump to determine infusion rate.
AND
Confirm with the following calculation:
Infusion rate (mL/h) = Dose (mcg/kg/min) x Weight (kg) x 60 (min/h) divided by Concentration (mcg/mL).
AND
Confirm with the following calculation:
Infusion rate (mL/h) = Dose (mcg/kg/min) x Weight (kg) x 60 (min/h) divided by Concentration (mcg/mL).
Comments
Isoproterenol should not be used for the treatment of asystole or cardiac arrest
Not considered drug of choice for bradycardia.
Isoproterenol increases myocardial oxygen demand and increased contractility.
May cause flushing, hypotension, ventricular arrythmias and myocardial ischemia.
Tachycardia is the major dose-limiting factor.
Do not use for digitalis toxicity.
Significant degradation occurs above pH 6.
References
44, 192
Last Edited
2019-01-16 19:53:15