KETOCONAZOLE
(Nizoral)Standard Prescription
ketoconazole__mg PO Q__H (__mg/kg/24hr)
Dosages
Children > 2 years old:
3.3 - 6.6 mg/kg/dose PO daily.
Adults:
200-400 mg/dose PO daily.
3.3 - 6.6 mg/kg/dose PO daily.
Adults:
200-400 mg/dose PO daily.
Mechanism of Action
Azole antifungal agent
Forms Supplied
tablet: 200 mg
Comments
Adverse Effects: Hepatotoxicity, GI symptoms, rash, anaphylaxis, thrombocytopenia, hemolytic anemia, gynecomastia and adrenal insufficiency.
Perform periodic liver function tests and use with caution in patients with impaired hepatic function.
A potent inhibitor of the CYP450 enzyme system.
Check for drug interactions; concomitant use with cisapride, domperidone may cause cardiac arrhythmias. Concomitant use with midazolam may cause excessive sedation and respiratory depression.
Tablets require adequate gastric acidity for dissolution. In patients receiving H 2 -antagonists (eg ranitidine) or proton pump inhibitors (eg omeprazole) administer ketoconazole with a cola beverage.
Do not administer with antacids (space doses by 2 hrs).
Perform periodic liver function tests and use with caution in patients with impaired hepatic function.
A potent inhibitor of the CYP450 enzyme system.
Check for drug interactions; concomitant use with cisapride, domperidone may cause cardiac arrhythmias. Concomitant use with midazolam may cause excessive sedation and respiratory depression.
Tablets require adequate gastric acidity for dissolution. In patients receiving H 2 -antagonists (eg ranitidine) or proton pump inhibitors (eg omeprazole) administer ketoconazole with a cola beverage.
Do not administer with antacids (space doses by 2 hrs).
References
44
Last Edited
2022-07-04 18:57:47