LABETALOL
(Trandate)Standard Prescription
labetalol__mg PO Q__H (__mg/kg/24hr)
labetalol__mg IV loading dose over 2 minutes (__mg/kg/dose)
labetalol__mg/kg/hr continuous IV infusion
labetalol__mg IV loading dose over 2 minutes (__mg/kg/dose)
labetalol__mg/kg/hr continuous IV infusion
Dosages
Oral: initial dose: 0.5-1.5 mg/kg/dose BID. Titrate to effect or maximum dose of 5-6 mg/kg/dose BID, Maximum 1200 mg per day.
Hypertensive Emergencies:
IV bolus Dose: 0.2-1 mg/kg/dose IV. Maximum40 mg/dose. May be repeated at 10 min. intervals until desired BP has been achieved.
Hypertensive Emergencies:
IV bolus Dose: 0.2-1 mg/kg/dose IV. Maximum40 mg/dose. May be repeated at 10 min. intervals until desired BP has been achieved.
Continuous IV infusion:
0.25 mg/kg/hr; rate may be increased by increments of 0.5 mg/kg/hr as needed to control BP to a maximum rate of 3 mg/kg/hr.
Mechanism of Action
Alpha and beta adrenergic blocker.
Forms Supplied
tablet: 100 mg, 200 mg
injection: 5 mg/mL, 20 mL multi-dose vial.
BCCH suspension: 10 mg/mL
injection: 5 mg/mL, 20 mL multi-dose vial.
BCCH suspension: 10 mg/mL
Comments
Alpha and beta adrenergic blocker.
Can cause postural hypotension.
Contraindicated in asthma/bronchospasm, 2nd and 3rd degree heart block, cardiogenic shock, severe bradycardia, uncontrolled heart failure.
IV to be given in Critical Care areas and 3F only.
Oral bioavailability is 25% (extensive first-pass metabolism). Bioavailability is increased in liver disease.
BP effects can persist up to 24 hours after stopping IV infusion.
Can cause postural hypotension.
Contraindicated in asthma/bronchospasm, 2nd and 3rd degree heart block, cardiogenic shock, severe bradycardia, uncontrolled heart failure.
IV to be given in Critical Care areas and 3F only.
Oral bioavailability is 25% (extensive first-pass metabolism). Bioavailability is increased in liver disease.
BP effects can persist up to 24 hours after stopping IV infusion.
References
1, 44, 60, 193, 261
Last Edited
2022-07-04 03:35:02