VANCOMYCIN
(Vancocin)Standard Prescription
vancomycin __mg IV Q__H (__mg/kg/24hr)
vancomycin__mg PO Q__H (__mg/kg/24hr)
vancomycin__mg PO Q__H (__mg/kg/24hr)
Dosages
Infants and Children:
15 mg/kg/dose IV Q6H.
Meningitis or other Serious Infection:
Adults: 15-20 mg/kg/dose IV Q8-12H.
15 mg/kg/dose IV Q6H.
Meningitis or other Serious Infection:
15 mg/kg/dose IV Q6H May consider 20 mg/kg/dose IV Q6H if seriously ill and normal renal function.
Clostridium difficile Colitis:
Children: 10 mg/kg/dose PO/NG QID x 10-14 days. Maximum 125 mg/dose
Adults: 15-20 mg/kg/dose IV Q8-12H.
A loading dose of 20-25 mg/kg/dose IV can be given in seriously ill patients.
Adults (C. difficile colitis): 125 mg PO/NG QID X 10-14 days.
May increase to 500 mg/dose PO/NG QID if complicated C. difficile infection with ileus or toxic megacolon.Mechanism of Action
Glycopeptide antibiotic
Forms Supplied
capsule: 125 mg, 250 mg
oral solution (BCCH): 10 mg/mL
injection: 500 mg/vial
oral solution (BCCH): 10 mg/mL
injection: 500 mg/vial
Comments
Dose adjustments are required for renal impairment.
Metronidazole is preferred therapy for antibiotic-associated colitis; vancomycin should be avoided due to the emergence of vancomycin-resistant enterococcus; if vancomycin is indicated, use oral form only as parenteral vancomycin does not achieve adequate concentrations in gut. Refer to BCCH C difficile Guideline.
Consider AUC/MIC monitoring with peak and trough levels.
Refer to Therapeutic Drug Monitoring Table and Vancomycin AUC/MIC Therapeutic Drug Monitoring Guideline (in References and Supplementary, white pages in print copy).
Refer to Therapeutic Drug Monitoring Table and Vancomycin AUC/MIC Therapeutic Drug Monitoring Guideline (in References and Supplementary, white pages in print copy).
References
6, 44, 56, 171, 172
Last Edited
2024-04-13 05:10:29