MEPERIDINE
(Demerol, Pethidine)Standard Prescription
meperidine__mg IV Q__H x__dose(s) (prn) (__mg/kg/dose)
Dosages
Amphotericin-induced Chills:
0.25 to 0.5 mg/kg/dose IV x 1 or 2 doses/24 hr.
0.25 to 0.5 mg/kg/dose IV x 1 or 2 doses/24 hr.
Mechanism of Action
Opioid analgesic
Forms Supplied
injection: 50 mg/mL, 75 mg/mL, 100 mg/mL
Comments
Not recommended for pain relief.
Meperidine is considered 4th line therapy for ampho-induced chills (after failure of steroids, antihistamine or acetaminophen).
Use with caution in renal failure: Metabolite of meperidine has CNS effects (tremors, seizures).
If used to treat amphotericin-induced chills, consider other concurrent narcotics or CNS depressants being used to avoid excessive sedation.
References
32, 38, 121
Last Edited
2022-04-08 04:03:31