MESALAMINE
(Synonyms: 5-ASA, mesalazine; Brand names: Asacol, Novo-5ASA, Pentasa, Salofalk)Standard Prescription
mesalamine mg PO__(frequency) ( mg/kg/24hr).
Dosages
Oral:
30-40 mg/kg/dose PO BID (Max 4.8 g/day or up to 100 mg/kg/day)
Suppository:
25 mg/kg PR QHS (Max 1 g/dose)
Maximum combined PO & PR daily dose: 6.4 g
Enema:
30-40 mg/kg/dose PO BID (Max 4.8 g/day or up to 100 mg/kg/day)
Suppository:
25 mg/kg PR QHS (Max 1 g/dose)
Maximum combined PO & PR daily dose: 6.4 g
Enema:
4 g PR QHS for acute episodes
2 g PR QHS to prevent relapse
Mechanism of Action
5-ASA derivative; Anti-inflammatory
Forms Supplied
enteric coated tablet:
400 mg (Novo-5ASA)
500 mg (Salofalk)
500 mg ER (Pentasa)
enema:
2 g, 4 g in 58.2 mL (Salofalk)
1g in 100 mL (Pentasa)
suppository:
500 mg (Salofalk)
1 g (Pentasa)
400 mg (Novo-5ASA)
500 mg (Salofalk)
500 mg ER (Pentasa)
enema:
2 g, 4 g in 58.2 mL (Salofalk)
1g in 100 mL (Pentasa)
suppository:
500 mg (Salofalk)
1 g (Pentasa)
Comments
Do not crush tablets; swallow whole.
Once daily dosing is equally effective but may result in more side effects.
Maintenance doses should be similar. Lower doses may be considered after a period of sustained remission. The minimum effective dose in adults is 1.2 g/day.
Mesalamine products are NOT interchangeable as per the College of Pharmacists of BC due to differences in dissolution characteristics.
Contraindicated in patients with salicylate allergy and severe renal or hepatic impairment.
Do not administer with medications that can lower intestinal pH.
Once daily dosing is equally effective but may result in more side effects.
Maintenance doses should be similar. Lower doses may be considered after a period of sustained remission. The minimum effective dose in adults is 1.2 g/day.
Mesalamine products are NOT interchangeable as per the College of Pharmacists of BC due to differences in dissolution characteristics.
Contraindicated in patients with salicylate allergy and severe renal or hepatic impairment.
Do not administer with medications that can lower intestinal pH.
References
1, 32, 44
Last Edited
2019-04-28 20:06:20