METHADONE
Standard Prescription
methadone__mg PO Q__H
Dosages
Pediatrics:
Analgesia:
Analgesia:
- Conversion to methadone from other opioids takes at least 3 days and is to be supervised by the Acute, Complex or Palliative Pain Service.
- Dose of methadone depends on the opioid used, opioid dose and length of therapy.
- Refer to PICU guidelines.
Mechanism of Action
Opioid analgesic
Forms Supplied
Oral Solution: 1 mg/mL
Tablets: 1 mg, 5 mg
Suppositories: 3 mg, 6 mg, 10 mg, 20 mg (made locally; ordered as needed)
(IV form not available in Canada)
Tablets: 1 mg, 5 mg
Suppositories: 3 mg, 6 mg, 10 mg, 20 mg (made locally; ordered as needed)
(IV form not available in Canada)
Comments
- May only be ordered by physicians licensed to prescribe methadone
- Do not use methadone for breakthrough pain.
- Methadone should not be used in opioid naive patients (risk of respiratory depression)
- Monitoring: Obtain ECG prior to start of therapy (may cause QT interval prolongation and serious arrhythmia)
- Monitor respiratory, cardiovascular, mental status (Refer to Opioid Administration Guidelines)
- Many drug interactions; check with pharmacy
- Overdoses: Overdoses may be reversed with naloxone but as half-life of methadone is very long, naloxone infusion and admission to PICU may be required
- Rectal absorption is similar to PO but is more variable between patients. Titration is required. Suppositories can be dosed Q8H
References
4
Last Edited
2021-02-20 19:16:08