METHYLDOPA

Standard Prescription

METHYLDOPA __mg IV q__h (__mg/kg/24hr)
METHYLDOPA __mg PO q__h (__mg/kg/24hr)

Dosages

Children:
IV: 
  • 2-4mg/kg/dose IV Q6-8H.
  • If no response in 4-6 hrs increase to 5-10mg/kg/dose. 
  • Maximum:  65 mg/kg/24 hr.
PO: 
  • Initial:  10 mg/kg/24 hr PO div. Q6-12H. 
  • Increase by 5-10 mg/kg/24 hr PRN Q2 days. 
  • Maximum:  65 mg/kg/24 hr or 3G/24hr.
Adults:
  • IV:  250-1000 mg Q6-8H.
  • PO:  250-750 mg Q6-12H.

Mechanism of Action


Forms Supplied

tablet:  , 250 mg,500mg
injection:  50 mg/mL

Comments

  • IV use for hypertensive crises only (other agents are preferred).
  • May require 7 days to achieve maximum effects with PO use.
  • Adjust dose in renal impairment
  • Use with caution in patients on lithium, haloperidol, propranolol or sympathomimetics and patients with active liver disease.
  • May interfere with lab tests such as creatinine,uric acid, catecholamines and give positive Coombs test

References

1, 44

Last Edited

2021-02-20 19:16:32