METHYLPREDNISOLONE
(Depo-Medrol, Solu-Medrol)Standard Prescription
methylprednisolone__mg IV Q__H (__mg/kg/24hr)
methylprednisolone__mg IM Q__H (__mg/m2/24hr)
methylprednisolone__mg IM Q__H (__mg/m2/24hr)
Dosages
Anti-inflammatory/Immunosuppressive:
0.05-0.8 mg/kg/dose IV Q12H (total daily dose may also be divided up to Q6H)
Acute Asthma:
1 mg/kg/dose (max: 60 mg/dose) IV Q6H x 24 hr, then switch to oral dexamethasone when symptoms improve
"Pulse Therapy":
0.05-0.8 mg/kg/dose IV Q12H (total daily dose may also be divided up to Q6H)
Acute Asthma:
1 mg/kg/dose (max: 60 mg/dose) IV Q6H x 24 hr, then switch to oral dexamethasone when symptoms improve
"Pulse Therapy":
10-30 mg IV 10-30 mg/kg/dose (max 1 g/dose) IV once daily x 1-3 days.
May be given for various conditions (e.g. polyarticular and systemic juvenile arthritis; SLE, vasculitis, severe glomerular nephritis and dermatomyositis).
Mechanism of Action
Corticosteroid
Forms Supplied
IM/IV injection: 40 mg/vial, 125 mg/vial, 500 mg/vial, 1 g/vial (sodium succinate)
IM Depo injection: 20 mg/mL, 40 mg/mL (acetate)
IM Depo injection: 20 mg/mL, 40 mg/mL (acetate)
Comments
4 mg methylprednisolone = 5 mg prednisone.
Acetate form (Depo) may be used for intra-articular or intralesional injection (although triamcinolone hexacetonide is preferred for joint injection)
References
44, 98, 127, 278, 279
Last Edited
2022-07-06 23:23:22