METOLAZONE
(Zaroxolyn)Standard Prescription
metolazone__mg PO__(frequency) (__mg/kg/24hr)
Dosages
Children:
0.1-0.2 mg/kg/dose PO once daily-BID.
Maximum: 10 mg BID.
Adult:
5-20 mg PO once daily
0.1-0.2 mg/kg/dose PO once daily-BID.
Maximum: 10 mg BID.
Adult:
5-20 mg PO once daily
Mechanism of Action
Thiazide diuretic
Forms Supplied
tablet: 2.5 mg
suspension (BCCH): 1 mg/mL
suspension (BCCH): 1 mg/mL
Comments
Concurrent administration of metolazone and furosemide significantly potentiates the diuretic effects of furosemide.
More effective than thiazide diuretics in impaired renal function; may be effective in GFRs as low as 20 mL/min.
Onset of action 1 hour.
More effective than thiazide diuretics in impaired renal function; may be effective in GFRs as low as 20 mL/min.
Onset of action 1 hour.
References
44, 192
Last Edited
2022-07-06 23:26:21