MILRINONE
(Primacor)Standard Prescription
milrinone__mcg IV x 1 loading dose
milrinone__mcg/kg/min continuous IV infusion
milrinone__mcg/kg/min continuous IV infusion
Dosages
Inotrope/Vasodilator:
Loading dose: 50 mcg/kg/dose IV over 10 min.
Maintenance: 0.25-1 mcg/kg/min by continuous IV infusion.
*NB: Loading doses in post-op open heart patients require approval from a pediatric intensive care physician.
Loading dose: 50 mcg/kg/dose IV over 10 min.
Maintenance: 0.25-1 mcg/kg/min by continuous IV infusion.
*NB: Loading doses in post-op open heart patients require approval from a pediatric intensive care physician.
Mechanism of Action
Bipyridine phosphodiesterase III inhibitor resulting in positive inotrope effects and vasodilatation
Forms Supplied
Injection: 1 mg/mL, 10 mL vials
Standard concentrations:
NICU: 100 mcg/mL in D5W
Other areas: 100 mcg/mL; 200 mcg/mL; 400 mcg/mL in D5W;
Comments
Bipyridine phosphodiesterase III inhibitor resulting in positive inotrope effects and vasodilatation.
Contraindicated in obstructive cardiac lesions such as pulmonary and aortic stenosis and coarctation of the aorta.
Side effects include: headache, dysrhythmias, hypotension, hypokalemia, abnormal liver function tests, tremor, thrombocytopenia (lower incidence than amrinone), bronchospasm.
Half-life is about 2 hrs in children with normal renal function.
Half-life is prolonged in patients with renal dysfunction.
Side effects include: headache, dysrhythmias, hypotension, hypokalemia, abnormal liver function tests, tremor, thrombocytopenia (lower incidence than amrinone), bronchospasm.
Half-life is about 2 hrs in children with normal renal function.
Half-life is prolonged in patients with renal dysfunction.
References
44, 119
Last Edited
2019-07-01 05:43:55