n-ACETYLCYSTEINE
(Mucomyst, NAC)Standard Prescription
n-acetylcysteine__% solution__mL nebulized__(frequency)
n-acetylcysteine 20% solution__mL PO__(frequency)
n-acetylcysteine 10% solution__mL enema PR__(frequency)
n-acetylcysteine 10% solution__mL irritation into urinary catheter x 1
n-acetylcysteine 20% solution__mL PO__(frequency)
n-acetylcysteine 10% solution__mL enema PR__(frequency)
n-acetylcysteine 10% solution__mL irritation into urinary catheter x 1
Dosages
Acetaminophen Overdose:
See Poison Manual.
2 - 6 yr: 2000 - 3000 mg PO once
7 yr and older: 4000 - 6000 mg PO once
PR: 100 mL of 10% solution as enema once daily to QID.
Maintenance:
1 month - 2 yr: 100 - 500 mg PO TID-QID
2 yr and older: 1000 - 3000 mg PO TID-QID
Prevention:
1 month - 2 yr: 100 - 200 mg PO TID
2 - 11 yr: 200 mg PO TID
12 yr and older: 200-400 mg PO TID
Irrigation of Urinary Catheter:
10 mL of a 10% solution into catheter
See Poison Manual.
Treatment of Distal Intestinal Obstruction Syndrome (DIOS) in Cystic Fibrosis - Partial Obstruction Only
Acute treatment:
1 month - 2 yr: 400 -3000 mg PO once2 - 6 yr: 2000 - 3000 mg PO once
7 yr and older: 4000 - 6000 mg PO once
PR: 100 mL of 10% solution as enema once daily to QID.
Maintenance:
1 month - 2 yr: 100 - 500 mg PO TID-QID
2 yr and older: 1000 - 3000 mg PO TID-QID
Prevention:
1 month - 2 yr: 100 - 200 mg PO TID
2 - 11 yr: 200 mg PO TID
12 yr and older: 200-400 mg PO TID
Irrigation of Urinary Catheter:
10 mL of a 10% solution into catheter
Mechanism of Action
Acetaminophen antidote, Mucolytic
Forms Supplied
oral solution:
200 mg/mL (20%) 10 mL
100 mg/mL (10%) [BCCH]
injection: 200 mg/mL (20%) 10 mL, 30 mL
200 mg/mL (20%) 10 mL
100 mg/mL (10%) [BCCH]
injection: 200 mg/mL (20%) 10 mL, 30 mL
Comments
Side Effects: local irritation, bronchospasm, hemoptysis, stomatitis, rhinorrhea, nausea/vomiting.
To make a 10% rectal solution, the 20% solution should be diluted with an equal volume of SWI or sterile NS.
5% - 10% solution recommended for patients up to 2 years; 10 - 20% solution for patients above 2 years.
For oral use, may dilute with water, saline, cola, orange juice.
Ensure adequate hydration when using to treat Distal Intestinal Obstruction Syndrome.
To make a 10% rectal solution, the 20% solution should be diluted with an equal volume of SWI or sterile NS.
5% - 10% solution recommended for patients up to 2 years; 10 - 20% solution for patients above 2 years.
For oral use, may dilute with water, saline, cola, orange juice.
Ensure adequate hydration when using to treat Distal Intestinal Obstruction Syndrome.
References
1, 28, 32, 176, 680
Last Edited
2022-07-28 01:06:47