PENICILLAMINE
(Cuprimine)Standard Prescription
penicillamine __mg PO Q__H (__mg/kg/24 hr)
Dosages
Wilson's Disease:
Infants & children: 10 mg/kg/dose PO BID or 7 mg/kg/dose PO TID.
Adults: 500-750 mg PO BID or 250-500 mg/dose PO TID. Maximum 2 g/24 hours
Infants & children: 10 mg/kg/dose PO BID or 7 mg/kg/dose PO TID.
Adults: 500-750 mg PO BID or 250-500 mg/dose PO TID. Maximum 2 g/24 hours
Cystinuria:
Infants/Young Children: 7.5 mg/kg/dose PO QID. Maximum 4 g/24 hr
Older Children/Adults: 500 mg/dose PO QID (1-4 g/24 hr)
Mechanism of Action
Heavy metal antagonist; chelating agent.
Forms Supplied
capsule: 250 mg
A low usage item; not stocked at BCCH but can be obtained in 2 to 3 days.
A low usage item; not stocked at BCCH but can be obtained in 2 to 3 days.
Comments
Penicillamine has been associated with serious hematological and renal adverse effects. Routine monitoring of CBC and urinalysis Q1-2 weeks during first six months of therapy is recommended.
Dose adjustment is based on 24 hour urinary copper excretion (Wilson's Disease) or urinary cysteine excretion (cystinuria).
Give on empty stomach - give doses one hour before or 2 hours after meals. Avoid concomitant iron, antacids and milk.
Patients treated for Wilson's Disease or cystinuria should be supplemented with pyridoxine 25 - 50 mg per day.
Dose adjustment is based on 24 hour urinary copper excretion (Wilson's Disease) or urinary cysteine excretion (cystinuria).
Give on empty stomach - give doses one hour before or 2 hours after meals. Avoid concomitant iron, antacids and milk.
Patients treated for Wilson's Disease or cystinuria should be supplemented with pyridoxine 25 - 50 mg per day.
References
4, 44, 445
Last Edited
2019-08-13 01:38:05