PENTAMIDINE
Standard Prescription
pentamidine __mg IM/IV ___(frequency)
pentamidine __mg via nebulizer ___(frequency)
pentamidine __mg via nebulizer ___(frequency)
Dosages
Treatment of pneumocysitis jirovecii pneumonia (PCP):
4 mg/kg/24 hr IM/IV daily x 21 days.
Prophylaxis of pneumocysitis jirovecii pneumonia (PCP):
Inhalation
< 5 years old: 9 mg/kg/dose via nebulizer Q4 weeks. Maximum 300 mg/ per dose.
> 5 years old: 300 mg via nebulizer Q4 weeks.
4 mg/kg/24 hr IM/IV daily x 21 days.
Prophylaxis of pneumocysitis jirovecii pneumonia (PCP):
Inhalation
< 5 years old: 9 mg/kg/dose via nebulizer Q4 weeks. Maximum 300 mg/ per dose.
> 5 years old: 300 mg via nebulizer Q4 weeks.
Intravenous
4 mg/kg/dose IV Q4 weeks. Maximum 300 mg/doseMechanism of Action
Antimicrobial
Forms Supplied
Injection: 300 mg/vial
Comments
Second-line for the treatment or prophylaxis of pneumocystis jirovecii pneumonia. May consider for patients who are intolerant to or fail co-trimoxazole.
Adverse effects more common with treatment doses: hypoglycemia, nephrotoxicity, hypotension, increased liver enzymes, leukopenia, neutropenia, thrombocytopenia.
Cough and bronchospasm may occur with inhalation therapy. Pretreatment with bronchodilator may be beneficial.
Note: inhalation therapy requires special nebulization procedures; contact Respiratory Therapy.
Adverse effects more common with treatment doses: hypoglycemia, nephrotoxicity, hypotension, increased liver enzymes, leukopenia, neutropenia, thrombocytopenia.
Cough and bronchospasm may occur with inhalation therapy. Pretreatment with bronchodilator may be beneficial.
Note: inhalation therapy requires special nebulization procedures; contact Respiratory Therapy.
References
6, 13, 44
Last Edited
2022-08-24 19:23:59