ARGATROBAN
Standard Prescription
argatroban __mcg (__mcg/kg) IV x 1 dose (loading dose)
argatroban __mcg/kg/min continuous IV infusion
argatroban __mcg/kg/min continuous IV infusion
Dosages
Initial dose:
0.75 mcg/kg/min by continuous IV infusion
Increments of 0.1-0.25 mcg/kg/min to target PTT 1.5-3x normal range
Lower doses in hepatic failure recommended:
0.2 microgram/kg/min by continuous IV infusion
Increments of 0.05 mcg/kg/min
0.75 mcg/kg/min by continuous IV infusion
Increments of 0.1-0.25 mcg/kg/min to target PTT 1.5-3x normal range
Lower doses in hepatic failure recommended:
0.2 microgram/kg/min by continuous IV infusion
Increments of 0.05 mcg/kg/min
Mechanism of Action
Direct thrombin inhibitor for heparin induced thrombocytopenia
Forms Supplied
Injection: 250 mg/2.5 mL Vial
Comments
Haematology Consult is required for use
Direct Thrombin inhibitor for Heparin induced thrombocytopenia
Target PTT 1.5-3 x normal range, check PTT 2hr post bolus
Risk of bleeding, hypersensitivity
discontinue other parenteral anticoagulants prior to initiation
caution if increased risk of bleeding (post LP, recent surgery, uncontrolled hypertension)
avoid NSAIDs or other antiplatelet agents
Direct Thrombin inhibitor for Heparin induced thrombocytopenia
Target PTT 1.5-3 x normal range, check PTT 2hr post bolus
Risk of bleeding, hypersensitivity
discontinue other parenteral anticoagulants prior to initiation
caution if increased risk of bleeding (post LP, recent surgery, uncontrolled hypertension)
avoid NSAIDs or other antiplatelet agents
References
90, 117, 122, 149
Last Edited
2018-11-25 04:28:22