PREGABALIN
(Lyrica)Standard Prescription
pregabalin __mg PO ___(frequency)
Dosages
Neuropathic pain:
Children > 4 years:
11 to < 30 kg: Initial: 1.75 mg/kg/dose PO BID (max 14 mg/kg/day or 600 mg/day)
>30 kg :1.25 mg/kg/dose PO BID (max 10 mg/kg/day or 600 mg/day)
Round dose to nearest capsule size
Increase as tolerated
Maintenance: 150 mg/dose PO BID
Children > 4 years:
11 to < 30 kg: Initial: 1.75 mg/kg/dose PO BID (max 14 mg/kg/day or 600 mg/day)
>30 kg :1.25 mg/kg/dose PO BID (max 10 mg/kg/day or 600 mg/day)
Round dose to nearest capsule size
Increase as tolerated
Adults:
Initial: 75 mg /dose PO BID for first weekMaintenance: 150 mg/dose PO BID
Maximum: 600 mg/day
Fibromyalgia:
Children >= 12 years and adolescents:
Initial: 37.5 mg PO BID x 1 week then titrate based on response (usual dose: 75-225 mg BID)
Maximum: 450 mg/day
Children >= 12 years and adolescents:
Initial: 37.5 mg PO BID x 1 week then titrate based on response (usual dose: 75-225 mg BID)
Maximum: 450 mg/day
Mechanism of Action
Analgesic.
Forms Supplied
Capsule: 25 mg, 75 mg
Comments
Pregabalin is similar in mechanism to gabapentin.
Indicated for the treatment of chronic pain in patients intolerant to or inadequately controlled on other analgesics.
Withdrawal symptoms may develop if abruptly discontinued; taper over 1 to 2 weeks.
Dose adjustments needed in renal insufficiency.
Evidence of benefit in acute pain management in children is inconclusive.
Pediatric dose is extrapolated from adult data and limited small retrospective studies in children.
Doses above 300 mg/day may be associated with an increase in adverse effects without added analgesia.
May divide total daily dose TID instead of BID if increased sedation following each dose.
Equivalency conversion from gabapentin to pregabalin is 6:1 .
Indicated for the treatment of chronic pain in patients intolerant to or inadequately controlled on other analgesics.
Withdrawal symptoms may develop if abruptly discontinued; taper over 1 to 2 weeks.
Dose adjustments needed in renal insufficiency.
Evidence of benefit in acute pain management in children is inconclusive.
Pediatric dose is extrapolated from adult data and limited small retrospective studies in children.
Doses above 300 mg/day may be associated with an increase in adverse effects without added analgesia.
May divide total daily dose TID instead of BID if increased sedation following each dose.
Equivalency conversion from gabapentin to pregabalin is 6:1 .
References
14, 44, 411, 584, 585
Last Edited
2022-09-09 02:12:20