PRIMIDONE
(Mysoline)Standard Prescription
primidone __mg PO ___(frequency) (__mg/kg/24 hr)
Dosages
< 8 years old:
Initial: 125 mg/24 hr PO once daily
Increment: 125 mg/24 hr PO weekly
Maintenance: 10 to 25 mg/kg/24 hr PO div. TID to QID
> 8 years - Adult:
Initial: 250 mg/24 hr PO once daily
Increment: 250 mg/24 hr PO weekly
Maintenance: 0.75 to 1.5 g/24 hr PO div. TID to QID
Initial: 125 mg/24 hr PO once daily
Increment: 125 mg/24 hr PO weekly
Maintenance: 10 to 25 mg/kg/24 hr PO div. TID to QID
> 8 years - Adult:
Initial: 250 mg/24 hr PO once daily
Increment: 250 mg/24 hr PO weekly
Maintenance: 0.75 to 1.5 g/24 hr PO div. TID to QID
Mechanism of Action
Anticonvulsant; barbiturate.
Forms Supplied
Tablet: 125 mg, 250 mg
Liquid (BCCH): 50 mg/mL
Liquid (BCCH): 50 mg/mL
Comments
- Metabolized to phenobarbital.
- Phenobarbital levels may be monitored.
- Therapeutic Range: phenobarbital 65 to 170 micromol/L
- Do not discontinue abruptly.
References
Last Edited
2021-02-20 19:18:27