PROCHLORPERAZINE
(Stemetil)Standard Prescription
prochlorperazine __mg PO/PR ___(frequency) (__mg/kg/24 hr)
prochlorperazine __mg IM/IV ___(frequency) (__mg/kg/24 hr)
prochlorperazine __mg IM/IV ___(frequency) (__mg/kg/24 hr)
Dosages
Anti-emetic dose:
Children
9-13 kg: 2.5 mg/dose PO once daily to BID PRN. Max: 7.5 mg/day
>13-18 kg: 2.5 mg/dose PO BID-TID PRN. Max: 10 mg/day
>18-39 kg: 2.5 mg/dose PO TID or 5 mg/dose PO BID PRN. Max : 15 mg/day
>39 kg: 5-10 mg PO TID-QID PRN. Max : 40 mg/day
Children
9-13 kg: 2.5 mg/dose PO once daily to BID PRN. Max: 7.5 mg/day
>13-18 kg: 2.5 mg/dose PO BID-TID PRN. Max: 10 mg/day
>18-39 kg: 2.5 mg/dose PO TID or 5 mg/dose PO BID PRN. Max : 15 mg/day
>39 kg: 5-10 mg PO TID-QID PRN. Max : 40 mg/day
Mechanism of Action
Piperazine phenothiazine antipsychotic.
Forms Supplied
tablet: 5 mg, 10 mg
liquid: 1 mg/mL
suppository: 10 mg
liquid: 1 mg/mL
suppository: 10 mg
Comments
Extrapyramidal symptoms (EPS) and sedation are common in children.
If EPS occurs, discontinue prochlorperazine and treat with diphenhydramine or benztropine
Onset of action: 30-40 min.
Fatal, life-threatening and persistent adverse effects are rare but suggest that prochlorperazine be reserved for use where other agents have been ineffective.
References
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Last Edited
2022-09-08 05:22:10