ATROPINE
Standard Prescription
atropine __mg IV/IM/SC/PO/ETT x__dose(s){PRN} (__mg/kg/dose)
Dosages
Pre-op (inhibit secretions):
Infants & Children < 5 kg: 0.02 mg/kg/dose SC/IV/IM/PO. Maximum: 0.6 mg/dose
Infants & Children > 5 kg: 0.01-0.02 mg/kg/dose SC/IV/IM/PO. Maximum: 0.4 mg/dose
Adults: 0.5 mg/dose IM/IV/SC
CPR (bradycardia):
0.02 mg/kg/dose IV/IO Q5 min x 2 doses PRN. Max single dose 0.5 mg
Max total dose:
Children: 0.5 mg x 2 = 1mg
Adolescents and Adults: 0.5mg x6 = 3 mg
0.04-0.06 mg/kg via ETT. Dilute with NS to a volume of 3-5 mL and follow with several positive pressure ventilations.
Organophosphate Poisoning:
Consult Drug and Poison Centre
Infants & Children < 5 kg: 0.02 mg/kg/dose SC/IV/IM/PO. Maximum: 0.6 mg/dose
Infants & Children > 5 kg: 0.01-0.02 mg/kg/dose SC/IV/IM/PO. Maximum: 0.4 mg/dose
Adults: 0.5 mg/dose IM/IV/SC
CPR (bradycardia):
0.02 mg/kg/dose IV/IO Q5 min x 2 doses PRN. Max single dose 0.5 mg
Max total dose:
Children: 0.5 mg x 2 = 1mg
Adolescents and Adults: 0.5mg x6 = 3 mg
0.04-0.06 mg/kg via ETT. Dilute with NS to a volume of 3-5 mL and follow with several positive pressure ventilations.
Organophosphate Poisoning:
Consult Drug and Poison Centre
Children <12 years: 0.05 mg/kg/dose IV/IO initially; then doubling the dose every 5 min. until control of excessive bronchial secretions, and correction of significant bradycardia and hypotension (i.e. resolution of muscarinic symptoms).
Children >=12 years: 1 mg/dose IV/IO initially; then repeated by doubling the dose every 5 min. until muscarinic symptoms reverse Mechanism of Action
Anticholinergic agent
Forms Supplied
Injection:
0.1 mg/mL (PFS)
0.4 mg/mL
0.6 mg/mL
0.1 mg/mL (PFS)
0.4 mg/mL
0.6 mg/mL
Comments
IV injection is given over 1 minute.
For endotracheal administration use higher doses (2-10 X IV dose). Dilute with NS to a volume of 3-5 mL and follow with several positive pressure ventilations.
Injectable form may be given orally and is well absorbed; peak plasma concentrations are achieved within 1 hour.
Toxic Anticholinergic Side Effects:
For endotracheal administration use higher doses (2-10 X IV dose). Dilute with NS to a volume of 3-5 mL and follow with several positive pressure ventilations.
Injectable form may be given orally and is well absorbed; peak plasma concentrations are achieved within 1 hour.
Toxic Anticholinergic Side Effects:
Red as a beet (skin flushing),
Dry as a bone (dry mouth, urinary retention),
Blind as a bat (blurred vision, photophobia),
Mad as a hatter (agitation),
Hot as a stove (anhidrosis).
References
37, 44
Last Edited
2021-11-09 05:59:05