TRANEXAMIC ACID
(Cyklokapron, Trans AMCA)Standard Prescription
tranexamic acid__mg PO{IV} Q__H (__mg/kg/dose)
Dosages
Pediatric:
IV: 10 mg/kg/dose IV TID-QID.
PO: 10-20 mg/kg/dose BID-QID or 25 mg/kg/dose TID
PO: 1-1.5 g/dose BID-QID.
IV: 10 mg/kg/dose IV TID-QID.
PO: 10-20 mg/kg/dose BID-QID or 25 mg/kg/dose TID
Adolescents:
IV: 10 mg/kg/dose TID-QID.PO: 1-1.5 g/dose BID-QID.
Trauma-associated hemorrhage (only if within 3 hours of injury):
15 mg/kg/dose IV once (Maximum 1 gram/dose), then may consider 2 mg/kg/hour IV infusion for 8 hours (125 mg/hr) or until bleeding stops (Maximum 1 gram over 8 hours)Mechanism of Action
Hematostatic agent; antifibrinolytic
Reversibly blocks lysine binding sites on plasminogen to prevent fibrin degradation
Reversibly blocks lysine binding sites on plasminogen to prevent fibrin degradation
Forms Supplied
Tablet: 500 mg
Injection: 500 mg/5 mL
Oral suspension (BCCH):100 mg/mL
Injection: 500 mg/5 mL
Oral suspension (BCCH):100 mg/mL
Comments
Reduce dose in patients with renal impairment.
Absorption from G.I. tract is about 40%.
Time to peak activity: PO: 3 hrs; IV: 5 minutes
Tranexamic acid may be safely given with short courses (2-5 days) of combination oral contraceptives.
Associated with increased mortality when given for trauma-associated hemorrhage after 3 hours of injury.
References
4, 32 , 44, 413, 448, 453, 475, 476, 477, 666
Last Edited
2022-09-12 00:38:26