SODIUM POLYSTYRENE SULFONATE
(Kayexalate)Standard Prescription
sodium polystyrene sulfonate__g PO{PR} Q__H
Dosages
Children:
Usual Dose
PO: 1 g/kg/dose Q6H (max 15 g/dose)PR: 1 g/kg/dose Q2-6H (max 50 g/dose)
Adults:
PO: 15-30g once daily-QID
(Maximum daily dose=60 grams)
PR: 30-50 g Q6H
Mechanism of Action
Cation exchange resin that exchanges sodium for potassium across the large intestine
Forms Supplied
powder 1 level teaspoon = 3.5 g of sodium polystyrene sulfonate
Comments
Exchange ratio is 1 mmol K+ per gram of resin.
Each gram of sodium polystyrene sulfonate contains 4.1 mEq of sodium.
Onset of action 2-24 hours.
May alter absorption of oral medications:PO administration ideally should be spaced by 3 hours from other medications.
Powder: to give orally or by NG/NJ, mix with 3-4 mL water or D5W or D10W per gram of powder. To give rectally, mix to a concentration of 0.3-0.5 gram/mL with D5W. Do not give sorbitol suspension rectally
Retain enema in colon for at least 30-60 min. Rectal route of administration is less effective than oral.
Can be added to formula under guidance of a dietitian. Add prescribed amount of sodium polystyrene sulfonate to volume of formula. Maximum dose is 6 grams per liter of formula. Stir well, then let stand in fridge for 1 hour. Carefully pour off the top layer, leaving the brown slurry behind. Discard slurry
Do not administer with fruit juices containing K+,, antacids or Mg++ containing laxatives (risk of metabolic alkalosis) or Al+++ (risk of intestinal obstruction)
Each gram of sodium polystyrene sulfonate contains 4.1 mEq of sodium.
Onset of action 2-24 hours.
May alter absorption of oral medications:PO administration ideally should be spaced by 3 hours from other medications.
Powder: to give orally or by NG/NJ, mix with 3-4 mL water or D5W or D10W per gram of powder. To give rectally, mix to a concentration of 0.3-0.5 gram/mL with D5W. Do not give sorbitol suspension rectally
Retain enema in colon for at least 30-60 min. Rectal route of administration is less effective than oral.
Can be added to formula under guidance of a dietitian. Add prescribed amount of sodium polystyrene sulfonate to volume of formula. Maximum dose is 6 grams per liter of formula. Stir well, then let stand in fridge for 1 hour. Carefully pour off the top layer, leaving the brown slurry behind. Discard slurry
Do not administer with fruit juices containing K+,, antacids or Mg++ containing laxatives (risk of metabolic alkalosis) or Al+++ (risk of intestinal obstruction)
References
1, 44
Last Edited
2022-09-11 02:36:06