SUMATRIPTAN
(Imitrex)Standard Prescription
Sumatriptan __mg SC one dose ( __mg/kg/dose)
Sumatriptan __mg PO one dose ( __mg/kg/dose)
Sumatriptan __mg PO one dose ( __mg/kg/dose)
Dosages
Children 6-18 years
0.06 mg/kg/dose SC x 1 dose
(Max 6 mg/dose)
Children 8-12 years
25-50 mg/dose PO x 1 dose
Adolescents greater than 12 years
25-100 mg/dose PO x 1 dose
0.06 mg/kg/dose SC x 1 dose
(Max 6 mg/dose)
Children 8-12 years
25-50 mg/dose PO x 1 dose
Adolescents greater than 12 years
25-100 mg/dose PO x 1 dose
Mechanism of Action
Sumatriptan is a Serotonin receptor agonist and its primary therapeutic effect is in its inhibition of the release of Calcitonin gene-related peptide. It is used in the preventative treatment of migraine. It also decreases the activity of the trigeminal nerve, accounting for its efficacy in treating cluster headaches
Forms Supplied
injectable: 6 mg/ 0.5 mL
tablet: 25 mg, 50 mg, 100 mg
tablet: 25 mg, 50 mg, 100 mg
Comments
SC use only; do not administer IM.
Do not administer IV (may cause coronary vasospasm).
Efficacy of oral sumatriptan not well established in children.
Adverse effects appear to be dose-related.
Swallow tablet whole; do not split tablet.
Do not administer IV (may cause coronary vasospasm).
Efficacy of oral sumatriptan not well established in children.
Adverse effects appear to be dose-related.
Swallow tablet whole; do not split tablet.
References
7, 44, 483, 545, 546
1. Oskoui M. et al. Practice guideline update summary: Acute treatment of migraine in children and adolescents. Neurology. 2019;93:489-499
2. Wang G; Tan T; Liu Y; Hong P. Drugs for acute attack of pediatric migraine: A network meta-analysis of randomized controlled trials. Clinical Neurology and Neurosurgery 195 (2020) 105853
2. Wang G; Tan T; Liu Y; Hong P. Drugs for acute attack of pediatric migraine: A network meta-analysis of randomized controlled trials. Clinical Neurology and Neurosurgery 195 (2020) 105853
Last Edited
2022-04-24 18:56:17