BUPROPION
(Wellbutrin SR, Wellbutrin XL)Standard Prescription
bupropion SR __mg PO__(frequency)
bupropion XL __mg PO__ daily in am
bupropion XL __mg PO__ daily in am
Dosages
Depression:
Adolescents/Adults:
Initial dose: 100-150 mg PO QAM x 7 days, then increase as tolerated to 300 mg/day
(SR tablet: IN DIVIDED DOSES BID)
(XL tablet: ONCE DAILY in AM)
Maximum adult dose: 300 mg/24 hr
ADHD:
Children/Adolescents:
Initial: 100 mg PO QAM (SR tablet) Titrate over 2 weeks to a maximum of the lesser of 6 mg/kg/day or 300 mg/day
(divide doses BID if using SR tablet)
Smoking Cessation:
Initial: 150 mg PO qAM for 3 days, then increase as tolerated to 300 mg/day in divided doses BID (SR tablet) or ONCE DAILY in AM (XL tablet)
Adolescents/Adults:
Initial dose: 100-150 mg PO QAM x 7 days, then increase as tolerated to 300 mg/day
(SR tablet: IN DIVIDED DOSES BID)
(XL tablet: ONCE DAILY in AM)
Maximum adult dose: 300 mg/24 hr
ADHD:
Children/Adolescents:
Initial: 100 mg PO QAM (SR tablet) Titrate over 2 weeks to a maximum of the lesser of 6 mg/kg/day or 300 mg/day
(divide doses BID if using SR tablet)
Smoking Cessation:
Initial: 150 mg PO qAM for 3 days, then increase as tolerated to 300 mg/day in divided doses BID (SR tablet) or ONCE DAILY in AM (XL tablet)
Mechanism of Action
Forms Supplied
SR tablet: 100 mg, 150 mg (intended for administration in DIVIDED DOSES GIVEN BID).
XL tablet: 150 mg, 300 mg (intended for once daily administration).
Note: SR and XL tablet formulations are NOT interchangeable.
SR tablet: Maximum single dose = 150 mg. Doses above 150 mg/day to be given in divided doses BID, at least 8 hr apart.
XL tablet: 150 mg, 300 mg (intended for once daily administration).
Note: SR and XL tablet formulations are NOT interchangeable.
SR tablet: Maximum single dose = 150 mg. Doses above 150 mg/day to be given in divided doses BID, at least 8 hr apart.
Comments
Antidepressant. Controlled studies show benefit in ADHD and smoking cessation (adults)
Norepinephrine and dopamine reuptake inhibitor (NDRI)
Therapeutic effects usually seen after 7-28 days
Side effects include insomnia, headache, tremor, dizziness, GI distress, weight loss, anticholingeric effects, rash, seizures (dose related)
Contraindicated in patients with a pre-existing seizure disorder, eating disorder or alcohol use disorder
Swallow tablet whole. Do not split, crush or chew (may increase risk of seizures).
To reduce insomnia, Give XL tablet daily in the morning. With SR tablets, give first dose of BID regimen in the morning, and 2 nd dose 8 hr later (e.g. 0800h and 1600h).
Prescribers must be aware of "Black Box" warnings issued by Health Canada regarding the use of antidepressants in pediatrics.
Refer to the Health Canada website.
Norepinephrine and dopamine reuptake inhibitor (NDRI)
Therapeutic effects usually seen after 7-28 days
Side effects include insomnia, headache, tremor, dizziness, GI distress, weight loss, anticholingeric effects, rash, seizures (dose related)
Contraindicated in patients with a pre-existing seizure disorder, eating disorder or alcohol use disorder
Swallow tablet whole. Do not split, crush or chew (may increase risk of seizures).
To reduce insomnia, Give XL tablet daily in the morning. With SR tablets, give first dose of BID regimen in the morning, and 2 nd dose 8 hr later (e.g. 0800h and 1600h).
Prescribers must be aware of "Black Box" warnings issued by Health Canada regarding the use of antidepressants in pediatrics.
Refer to the Health Canada website.
References
4, 83
Last Edited
2018-12-03 04:43:59