CALCIUM POLYSTYRENE SULFONATE
(Resonium Calcium)Standard Prescription
calcium polystyrene sulfonate __g PO/PR__(frequency) (__g/kg/24hr)
Dosages
Hyperkalemia:
Children:
1 g/kg PO/PR once daily or divided TID-QIDAdults:
PO: 15g/dose PO TID-QID
PR: 30g once daily
For rectal administration: suspend the dose of powder in a proportional amount of D10W. Following retention of the enema, the colon should be irrigated to ensure adequate removal of the resin. Do not use sorbitol as a suspending agent.
Mechanism of Action
Cation exchange resin
Forms Supplied
Powder
The spoon provided in the jar contains 15 g of powder when filled level.
The spoon provided in the jar contains 15 g of powder when filled level.
Comments
Powder may be given orally mixed with small amount of jam, honey, water, or a non-K+ containing drink.
May alter absorption of oral medications:PO administration ideally should be spaced by 3 hours from other medications.
Onset of action of PO resin may be delayed 1-2 days, when resin reaches colon; exchange will continue until all resin is voided.
PR route is less effective than PO as retention time is shorter.
In vitro each gram of resin has a theoretical exchange capacity of 1.3 - 2 mmol K+ but in vivo the actual amount of K+ bound will be less, approximately 1mEq per gram of resin.
Preferred agent over sodium polystyrene sulfonate when sodium load of concern (eg. hypernatremia, hypertension, fluid overload).
Do not administer with fruit juices containing K+,, antacids or Mg++containing laxatives (risk of metabolic alkalosis) or Al+++ (risk of intestinal obstruction).
May alter absorption of oral medications:PO administration ideally should be spaced by 3 hours from other medications.
Onset of action of PO resin may be delayed 1-2 days, when resin reaches colon; exchange will continue until all resin is voided.
PR route is less effective than PO as retention time is shorter.
In vitro each gram of resin has a theoretical exchange capacity of 1.3 - 2 mmol K+ but in vivo the actual amount of K+ bound will be less, approximately 1mEq per gram of resin.
Preferred agent over sodium polystyrene sulfonate when sodium load of concern (eg. hypernatremia, hypertension, fluid overload).
Do not administer with fruit juices containing K+,, antacids or Mg++containing laxatives (risk of metabolic alkalosis) or Al+++ (risk of intestinal obstruction).
References
4, 32
Last Edited
2022-06-16 03:54:12