CEFTRIAXONE
(Rocephin)Standard Prescription
ceftriaxone__mg IV Q H ( mg/kg/24 hr)
Dosages
Children:
Mild to Moderate Infections:
50-75 mg/kg/dose IM/IV once dailySerious Infections:
50 mg/kg/dose IM/IV Q12H. (100 mg/kg/24 h given once daily or div Q12H)
Maximum: 4000 mg/24 hr (meningitis) or 2000 mg/24 hr (other infections)
Adults:
Usual dose: 1-2 g IM/IV Q12-24H
Max 4 g/24 hr
Mechanism of Action
Third-generation cephalosporin antibiotic
Forms Supplied
Injection: 0.25 g, 1 g, 2 g vials
Comments
Spectrum of activity of ceftriaxone is very similar to cefotaxime.
For IM USE ONLY, ceftriaxone may be reconstituted with 1% lidocaine.
Due to the risk of ceftriaxone-calcium precipitates, which have caused serious cardiopulmonary events in infants, ceftriaxone must not be mixed or administered simultaneously with calcium containing IV solutions, including parenteral nutrition, neither co-administered nor via Y-site.
Infants > 28 days & children: ceftriaxone and calcium-containing solutions may be administered sequentially to one another if the infusion lines are thoroughly flushed between infusions with a compatible fluid.
For IM USE ONLY, ceftriaxone may be reconstituted with 1% lidocaine.
Due to the risk of ceftriaxone-calcium precipitates, which have caused serious cardiopulmonary events in infants, ceftriaxone must not be mixed or administered simultaneously with calcium containing IV solutions, including parenteral nutrition, neither co-administered nor via Y-site.
Infants > 28 days & children: ceftriaxone and calcium-containing solutions may be administered sequentially to one another if the infusion lines are thoroughly flushed between infusions with a compatible fluid.
Neonates: Ceftriaxone is contraindicated if they require (or are expected to require) treatment with calcium-containing IV solutions, including TPN.
Ceftriaxone displaces bilirubin from albumin binding sites which can result in hyperbilirubinemia; use caution in neonates.
References
6, 44, 229
Last Edited
2022-06-16 00:17:25