CAPTOPRIL
(Capoten)Standard Prescription
captopril __mg PO__(frequency) (__mg/kg/dose)
Dosages
Neonates: refer to pink pages as doses are different in this age group
Infants and Children:
Initial: 0.1-0.5 mg/kg/dose PO BID-TID. *Titrate dose Q8-24H to a max of 6 mg/kg/24 hr
Adolescents:
Initial: 6.25-12.5 mg/dose PO BIDTID. (Max 6 mg/kg/24 hr or 450 mg/24 hr)
Adults:
12.5-25mg PO TID
Increase weekly if necessary by 25 mg/dose to a max.dose of 450 mg/24 hr
Infants and Children:
Initial: 0.1-0.5 mg/kg/dose PO BID-TID. *Titrate dose Q8-24H to a max of 6 mg/kg/24 hr
Adolescents:
Initial: 6.25-12.5 mg/dose PO BIDTID. (Max 6 mg/kg/24 hr or 450 mg/24 hr)
Adults:
12.5-25mg PO TID
Increase weekly if necessary by 25 mg/dose to a max.dose of 450 mg/24 hr
Mechanism of Action
Angiotensin-Converting Enzyme (ACE) inhibitor
Forms Supplied
Tablet: 6.25 mg, 12.5 mg, 25 mg, 50 mg
Suspension (BCCH): 1 mg/mL
Suspension (BCCH): 1 mg/mL
Comments
Reduce dose with impaired renal function.
Ensure adequate hydration; monitor serum creatinine and potassium after starting or increasing dose.
Severe hypotension may occur in patients who are sodium and/or volume depleted; use lower initial doses in these patients
caution in bilateral renal artery stenosis
contraindicated in all stages of pregnancy; discuss contraception with all females of childbearing age.
Onset of hypotensive effect: 15 min.; peak 60-90 min.,duration 6-8 hrs
Dose titration: dose may be increased with each dosing interval; monitor vitals every 30 minutes x 2 after each dose change
37.5 mg of captopril is approximately equivalent to 5 mg of enalapril or 2.5 mg of ramipril
May cause hyperkalemia; caution with potassium supplements and sparing agents
NSAIDs may blunt the hypotensive effects
Ensure adequate hydration; monitor serum creatinine and potassium after starting or increasing dose.
Severe hypotension may occur in patients who are sodium and/or volume depleted; use lower initial doses in these patients
caution in bilateral renal artery stenosis
contraindicated in all stages of pregnancy; discuss contraception with all females of childbearing age.
Onset of hypotensive effect: 15 min.; peak 60-90 min.,duration 6-8 hrs
Dose titration: dose may be increased with each dosing interval; monitor vitals every 30 minutes x 2 after each dose change
37.5 mg of captopril is approximately equivalent to 5 mg of enalapril or 2.5 mg of ramipril
May cause hyperkalemia; caution with potassium supplements and sparing agents
NSAIDs may blunt the hypotensive effects
References
1, 29, 141, 192, 193
Last Edited
2018-12-09 05:20:40