CHLORAMPHENICOL
Standard Prescription
chloramphenicol __mg IV Q H (__mg/kg/24h)
chloramphenicol 0.5% eye drops- Instill one drop in__eye Q__H
chloramphenicol 1% eye ointment- Apply to __eye Q__H
chloramphenicol 0.5% eye drops- Instill one drop in__eye Q__H
chloramphenicol 1% eye ointment- Apply to __eye Q__H
Dosages
Meningitis:
18.75-25 mg/kg/dose IV Q6H
Max: 1 g/dose
Other infections:
12.5-25 mg/kg/dose IV Q6H
Max: 1000 mg/dose
18.75-25 mg/kg/dose IV Q6H
Max: 1 g/dose
Other infections:
12.5-25 mg/kg/dose IV Q6H
Max: 1000 mg/dose
Mechanism of Action
Bacteriostatic antibiotic, inhibiting protein synthesis, preventing protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome.
Forms Supplied
Injection: 1 g
Comments
Serious blood dyscrasias have occurred with short and long-term use. Monitoring CBC during therapy is recommended.
Measurement of serum levels is subject to approval of a clinical microbiologist.
Use with caution in G6PD deficiency, renal or hepatic dysfunction and in neonates.
Therapeutic Peak Levels: 15-25 mg/L. Levels > 50 mg/L are associated with a greater incidence of toxic effects.
Refer to Therapeutic Drug Monitoring Table (white pages in print copy).
Use with caution in G6PD deficiency, renal or hepatic dysfunction and in neonates.
References
6, 44
Last Edited
2022-06-16 00:39:57