CHLORPROMAZINE
(Largactil)Standard Prescription
chlorpromazine __mg PO Q__H (__mg/kg/24hr)
Dosages
Children > 5 years: 0.5-1 mg/kg/dose PO Q6H (2-4 mg/kg/24 hr PO divided Q4-6H)
Maximum Dose:
(Initial 24 hr maximum limits shown above may be adjusted to higher 24 hr maximum limits with repeated use over time if necessary)
Maximum Dose:
5-12 years old: 75 mg/24 hr.
Adolescents may require 150 mg/ 24 hr.
(Initial 24 hr maximum limits shown above may be adjusted to higher 24 hr maximum limits with repeated use over time if necessary)
Mechanism of Action
Low-potency conventional antipsychotic (better used as a sedative than antipsychotic). Chlorpromazine is a very effective antagonist of D2 dopamine receptors.
Forms Supplied
tablet: 25 mg, 50 mg, 100 mg
Note : injectable formulation discontinued from Canadian market.
Note : injectable formulation discontinued from Canadian market.
Comments
Low-potency conventional antipsychotic (better used as a sedative than antipsychotic)
Causes sedation, hypotension and sialorrhea.
May cause hypotension, tachycardia, dizziness, QTc interval prolongation, lowered seizure threshold, anticholinergic symptoms.
Low risk of extrapyramidal symptoms (EPS); reversible with diphenhydramine or benztropine if EPS occurs. EPS may be more prominent in neurodiverse patients.
May cause drug interactions via CYP 2D6 inhibition.
Causes sedation, hypotension and sialorrhea.
May cause hypotension, tachycardia, dizziness, QTc interval prolongation, lowered seizure threshold, anticholinergic symptoms.
Low risk of extrapyramidal symptoms (EPS); reversible with diphenhydramine or benztropine if EPS occurs. EPS may be more prominent in neurodiverse patients.
May cause drug interactions via CYP 2D6 inhibition.
References
44, 83
Last Edited
2021-06-22 04:19:40